ClinDEF: A Dynamic Evaluation Framework for Large Language Models in Clinical Reasoning

Clinical diagnosis begins with doctor-patient interaction, during which physicians iteratively gather information, determine examination and refine differential diagnosis through patients' response. This dynamic clinical-reasoning process is poorly represented by existing LLM benchmarks that focus on static question-answering. To mitigate these gaps, recent methods explore dynamic medical frameworks involving interactive clinical dialogues. Although effective, they often rely on limited, contamination-prone datasets and lack granular, multi-level evaluation. In this work, we propose ClinDEF, a dynamic framework for assessing clinical reasoning in LLMs through simulated diagnostic dialogues. Grounded in a disease knowledge graph, our method dynamically generates patient cases and facilitates multi-turn interactions between an LLM-based doctor and an automated patient agent. Our evaluation protocol goes beyond diagnostic accuracy by incorporating fine-grained efficiency analysis and rubric-based assessment of diagnostic quality. Experiments show that ClinDEF effectively exposes critical clinical reasoning gaps in state-of-the-art LLMs, offering a more nuanced and clinically meaningful evaluation paradigm.

METS-CoV: A Dataset of Medical Entity and Targeted Sentiment on COVID-19 Related Tweets

The COVID-19 pandemic continues to bring up various topics discussed or debated on social media. In order to explore the impact of pandemics on people's lives, it is crucial to understand the public's concerns and attitudes towards pandemic-related entities (e.g., drugs, vaccines) on social media. However, models trained on existing named entity recognition (NER) or targeted sentiment analysis (TSA) datasets have limited ability to understand COVID-19-related social media texts because these datasets are not designed or annotated from a medical perspective. This paper releases METS-CoV, a dataset containing medical entities and targeted sentiments from COVID-19-related tweets. METS-CoV contains 10,000 tweets with 7 types of entities, including 4 medical entity types (Disease, Drug, Symptom, and Vaccine) and 3 general entity types (Person, Location, and Organization). To further investigate tweet users' attitudes toward specific entities, 4 types of entities (Person, Organization, Drug, and Vaccine) are selected and annotated with user sentiments, resulting in a targeted sentiment dataset with 9,101 entities (in 5,278 tweets). To the best of our knowledge, METS-CoV is the first dataset to collect medical entities and corresponding sentiments of COVID-19-related tweets. We benchmark the performance of classical machine learning models and state-of-the-art deep learning models on NER and TSA tasks with extensive experiments. Results show that the dataset has vast room for improvement for both NER and TSA tasks. METS-CoV is an important resource for developing better medical social media tools and facilitating computational social science research, especially in epidemiology. Our data, annotation guidelines, benchmark models, and source code are publicly available (https://github.com/YLab-Open/METS-CoV) to ensure reproducibility.